I have personally experienced a Herxheimer reaction to all sorts of things that are purportedly gentle so I always advise people to start slow. I know people that prefer to only use a drop of an essential oil on the soles of their feet before bedtime and others that can take 5-10 drops internally three times a day.
The blends I have created for Well Scent (and the Lyme population) are generally very well tolerated because they are uniquely balancing. While many of them are antimicrobial in nature. they are also beneficial in so many other ways too. For example, we include oils that support organ health, circulation, lymphatic drainage and the immune system. This helps to lessen some of the typical Herxhemier reactions but, again, I would still advise you start slow.